These data reinforce the
growing awareness that noncoding RNAs are key players in
tumor development by placing miRNAs in a central role in
a well-known tumor-suppressor network. As another tumor
suppressor,
Rb gene, there still never had published dataabout miRNAs involving its downstream pathway.
In the searching of normal control for the Rb cases, the
situation
we met in the study just like that in another mRNA
profiling study of Rb
Identification of miRNAs associated with tumorigenesisof retinoblastoma by miRNA microarray analysisJian-Jun Zhao & Juhua Yang & Jianhong Lin & Nan Yao &Yihua Zhu & Jianlong Zheng & Jianhua Xu &Jin Q. Cheng & Jian-Yin Lin & Xu Ma